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um-uc-5  (CancerTools Org)


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    Structured Review

    CancerTools Org um-uc-5
    Um Uc 5, supplied by CancerTools Org, used in various techniques. Bioz Stars score: 99/100, based on 68 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/um-uc-5/UM-UC-5/custom%40160437%4042537446
    Average 99 stars, based on 68 article reviews
    um-uc-5 - by Bioz Stars, 2026-09
    99/100 stars

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    Related Articles

    Biomarker Discovery:

    Article Title: Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
    Article Snippet: ls and sensitivity to AKT inhibitors [170]. Cell lines such as UM-UC-11 and UM-UC-13, which were relatively resistant to AZ7328 treatment, were found to have high basal phospho-AKT levels. Conversely, UM-UC-5 and UM-UC-6 cells (both contain activating PIK3CA mutations), which expressed relatively low phospho-AKT levels, were more sensitive to AKT inhibition, suggesting that phospho-AKT level may no

    Phospho-proteomics:

    Article Title: Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
    Article Snippet: ls and sensitivity to AKT inhibitors [170]. Cell lines such as UM-UC-11 and UM-UC-13, which were relatively resistant to AZ7328 treatment, were found to have high basal phospho-AKT levels. Conversely, UM-UC-5 and UM-UC-6 cells (both contain activating PIK3CA mutations), which expressed relatively low phospho-AKT levels, were more sensitive to AKT inhibition, suggesting that phospho-AKT level may no

    Inhibition:

    Article Title: Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
    Article Snippet: ls and sensitivity to AKT inhibitors [170]. Cell lines such as UM-UC-11 and UM-UC-13, which were relatively resistant to AZ7328 treatment, were found to have high basal phospho-AKT levels. Conversely, UM-UC-5 and UM-UC-6 cells (both contain activating PIK3CA mutations), which expressed relatively low phospho-AKT levels, were more sensitive to AKT inhibition, suggesting that phospho-AKT level may no

    Kinetic Assay:

    Article Title: Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
    Article Snippet: ls and sensitivity to AKT inhibitors [170]. Cell lines such as UM-UC-11 and UM-UC-13, which were relatively resistant to AZ7328 treatment, were found to have high basal phospho-AKT levels. Conversely, UM-UC-5 and UM-UC-6 cells (both contain activating PIK3CA mutations), which expressed relatively low phospho-AKT levels, were more sensitive to AKT inhibition, suggesting that phospho-AKT level may no

    Fluorescence:

    Article Title: Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
    Article Snippet: ls and sensitivity to AKT inhibitors [170]. Cell lines such as UM-UC-11 and UM-UC-13, which were relatively resistant to AZ7328 treatment, were found to have high basal phospho-AKT levels. Conversely, UM-UC-5 and UM-UC-6 cells (both contain activating PIK3CA mutations), which expressed relatively low phospho-AKT levels, were more sensitive to AKT inhibition, suggesting that phospho-AKT level may no

    Microscopy:

    Article Title: Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
    Article Snippet: ls and sensitivity to AKT inhibitors [170]. Cell lines such as UM-UC-11 and UM-UC-13, which were relatively resistant to AZ7328 treatment, were found to have high basal phospho-AKT levels. Conversely, UM-UC-5 and UM-UC-6 cells (both contain activating PIK3CA mutations), which expressed relatively low phospho-AKT levels, were more sensitive to AKT inhibition, suggesting that phospho-AKT level may no

    Fluorescence Microscopy:

    Article Title: Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
    Article Snippet: ls and sensitivity to AKT inhibitors [170]. Cell lines such as UM-UC-11 and UM-UC-13, which were relatively resistant to AZ7328 treatment, were found to have high basal phospho-AKT levels. Conversely, UM-UC-5 and UM-UC-6 cells (both contain activating PIK3CA mutations), which expressed relatively low phospho-AKT levels, were more sensitive to AKT inhibition, suggesting that phospho-AKT level may no

    Migration:

    Article Title: Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significance.
    Article Snippet: ls and sensitivity to AKT inhibitors [170]. Cell lines such as UM-UC-11 and UM-UC-13, which were relatively resistant to AZ7328 treatment, were found to have high basal phospho-AKT levels. Conversely, UM-UC-5 and UM-UC-6 cells (both contain activating PIK3CA mutations), which expressed relatively low phospho-AKT levels, were more sensitive to AKT inhibition, suggesting that phospho-AKT level may no



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    um-uc-5  (CancerTools Org)
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    CancerTools Org um-uc-5
    Um Uc 5, supplied by CancerTools Org, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    um-uc-5 cell line  (Millipore)
    90
    Millipore um-uc-5 cell line
    ( A ) Protein expression of OXPHOS cocktail — mitochondrial complex V (ATP5A), III (UQCRC2), II (SDHB), IV (MT-CO2), and I (NDUFB8) — in EA BLCA (UM-UC-3, T24) and AA BLCA (UM-UC-1, SCaBER) cell lines. ( B ) Mitochondrial complex activity in AA BLCA — UM-UC-1 ( n = 3), SCaBER ( n = 3) — cell lines compared with EA BLCA — UM-UC-3 ( n = 3), <t>UM-UC-5</t> ( n = 3) — cell lines; optical density (OD) of complex I activity was measured using specific substrates and normalized with the citrate synthase activity measured by colorimetric assay ( ****P < 0.0001). ( C ) Box-and-whisker plot represents ATP production in AA BLCA — UM-UC-1 ( n = 7), SCaBER ( n = 7) — and EA BLCA — UM-UC-3 ( n = 7), T24 ( n = 7) — cell lines measured by Seahorse assay. Data were normalized using cell number measured by CellTiter-Glo (*** *P < 0.0001). ( D and E ) Scatter plot represents the tumor growth (orthotopic) of AA BLCA (UM-UC-1) and EA BLCA (UM-UC-3) upon IACS-010759 (5 mg/kg) treatment compared with vehicle control. Luciferase measurements were performed over a period of 21 days — UM-UC-1: days 7 and 14 for Control ( n = 7), IACS-010759 treatment ( n = 8); day 21 for Control ( n = 6), IACS-010759 treatment ( n = 8); and UM-UC-3: day 7 for Control ( n = 8), IACS-010759 treatment ( n = 8); day 14 for Control ( n = 8), IACS-010759 treatment ( n = 7); day 21 for Control ( n = 7), IACS-010759 treatment ( n = 7) (unpaired t test for each time point; ***P < 0.001). ( F ) Plot represents the tumor growth (s.c.) from AA BLCA (SCaBER) cell line–derived xenografts treated with IACS-010759 (5 mg/kg; n = 5) compared with vehicle control ( n = 5) (unpaired t test for each time point; **P < 0.01 ; *P < 0.05 ) . ( G ) Protein expression of NDUFB8 (mitochondrial complex I protein) in EA ( n = 4; E1 to E4) and AA BLCA ( n = 4; A1 to A4) tissues measured by Western blot analysis. Significance was determined by unpaired 2-tailed student t test.
    Um Uc 5 Cell Line, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/um-uc-5/um+uc+9+cell+line/pmc11385078-216-15-21
    Average 90 stars, based on 1 article reviews
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    Image Search Results


    ( A ) Protein expression of OXPHOS cocktail — mitochondrial complex V (ATP5A), III (UQCRC2), II (SDHB), IV (MT-CO2), and I (NDUFB8) — in EA BLCA (UM-UC-3, T24) and AA BLCA (UM-UC-1, SCaBER) cell lines. ( B ) Mitochondrial complex activity in AA BLCA — UM-UC-1 ( n = 3), SCaBER ( n = 3) — cell lines compared with EA BLCA — UM-UC-3 ( n = 3), UM-UC-5 ( n = 3) — cell lines; optical density (OD) of complex I activity was measured using specific substrates and normalized with the citrate synthase activity measured by colorimetric assay ( ****P < 0.0001). ( C ) Box-and-whisker plot represents ATP production in AA BLCA — UM-UC-1 ( n = 7), SCaBER ( n = 7) — and EA BLCA — UM-UC-3 ( n = 7), T24 ( n = 7) — cell lines measured by Seahorse assay. Data were normalized using cell number measured by CellTiter-Glo (*** *P < 0.0001). ( D and E ) Scatter plot represents the tumor growth (orthotopic) of AA BLCA (UM-UC-1) and EA BLCA (UM-UC-3) upon IACS-010759 (5 mg/kg) treatment compared with vehicle control. Luciferase measurements were performed over a period of 21 days — UM-UC-1: days 7 and 14 for Control ( n = 7), IACS-010759 treatment ( n = 8); day 21 for Control ( n = 6), IACS-010759 treatment ( n = 8); and UM-UC-3: day 7 for Control ( n = 8), IACS-010759 treatment ( n = 8); day 14 for Control ( n = 8), IACS-010759 treatment ( n = 7); day 21 for Control ( n = 7), IACS-010759 treatment ( n = 7) (unpaired t test for each time point; ***P < 0.001). ( F ) Plot represents the tumor growth (s.c.) from AA BLCA (SCaBER) cell line–derived xenografts treated with IACS-010759 (5 mg/kg; n = 5) compared with vehicle control ( n = 5) (unpaired t test for each time point; **P < 0.01 ; *P < 0.05 ) . ( G ) Protein expression of NDUFB8 (mitochondrial complex I protein) in EA ( n = 4; E1 to E4) and AA BLCA ( n = 4; A1 to A4) tissues measured by Western blot analysis. Significance was determined by unpaired 2-tailed student t test.

    Journal: JCI Insight

    Article Title: Mitochondrial reprogramming by activating OXPHOS via glutamine metabolism in African American patients with bladder cancer

    doi: 10.1172/jci.insight.172336

    Figure Lengend Snippet: ( A ) Protein expression of OXPHOS cocktail — mitochondrial complex V (ATP5A), III (UQCRC2), II (SDHB), IV (MT-CO2), and I (NDUFB8) — in EA BLCA (UM-UC-3, T24) and AA BLCA (UM-UC-1, SCaBER) cell lines. ( B ) Mitochondrial complex activity in AA BLCA — UM-UC-1 ( n = 3), SCaBER ( n = 3) — cell lines compared with EA BLCA — UM-UC-3 ( n = 3), UM-UC-5 ( n = 3) — cell lines; optical density (OD) of complex I activity was measured using specific substrates and normalized with the citrate synthase activity measured by colorimetric assay ( ****P < 0.0001). ( C ) Box-and-whisker plot represents ATP production in AA BLCA — UM-UC-1 ( n = 7), SCaBER ( n = 7) — and EA BLCA — UM-UC-3 ( n = 7), T24 ( n = 7) — cell lines measured by Seahorse assay. Data were normalized using cell number measured by CellTiter-Glo (*** *P < 0.0001). ( D and E ) Scatter plot represents the tumor growth (orthotopic) of AA BLCA (UM-UC-1) and EA BLCA (UM-UC-3) upon IACS-010759 (5 mg/kg) treatment compared with vehicle control. Luciferase measurements were performed over a period of 21 days — UM-UC-1: days 7 and 14 for Control ( n = 7), IACS-010759 treatment ( n = 8); day 21 for Control ( n = 6), IACS-010759 treatment ( n = 8); and UM-UC-3: day 7 for Control ( n = 8), IACS-010759 treatment ( n = 8); day 14 for Control ( n = 8), IACS-010759 treatment ( n = 7); day 21 for Control ( n = 7), IACS-010759 treatment ( n = 7) (unpaired t test for each time point; ***P < 0.001). ( F ) Plot represents the tumor growth (s.c.) from AA BLCA (SCaBER) cell line–derived xenografts treated with IACS-010759 (5 mg/kg; n = 5) compared with vehicle control ( n = 5) (unpaired t test for each time point; **P < 0.01 ; *P < 0.05 ) . ( G ) Protein expression of NDUFB8 (mitochondrial complex I protein) in EA ( n = 4; E1 to E4) and AA BLCA ( n = 4; A1 to A4) tissues measured by Western blot analysis. Significance was determined by unpaired 2-tailed student t test.

    Article Snippet: UM-UC-3, T24, J82, and SCaBER (HTB-3) cell lines were purchased from ATCC, and UM-UC-1 and UM-UC-5 cell lines were purchased from Sigma-Aldrich.

    Techniques: Expressing, Activity Assay, Colorimetric Assay, Whisker Assay, Control, Luciferase, Derivative Assay, Western Blot